Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20490230 | 0.89 | HDAC4 (0.51) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL20490126 | 0.78 | HDAC3 (0.57) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL2839404 | 0.77 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL2842461 | 0.76 | HDAC4 (0.81) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL20490165 | 0.76 | HDAC4 (0.58) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL20490498 | 0.76 | HDAC4 (0.58) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL2839032 | 0.74 | HDAC4 (1.00) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL20490215 | 0.73 | HDAC4 (0.64) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL20490457 | 0.73 | HDAC4 (0.64) | HDAC4HDAC7HDAC5HDAC2HDAC3 | |
| SCHEMBL5766614 | 0.73 | ERN1 (0.51) | HDAC2APPERN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |
| CN-101679220-A | Histone deacetylase inhibitor | METHYLGENE INC | 2010-03-24 | — | — | CN | disclosed |