Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.45 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049588 | 0.86 | PIK3CG (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBDYRK1A | |
| SCHEMBL1991283 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBDYRK1A | |
| SCHEMBL1988679 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL1989608 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL1989504 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL4184362 | 0.81 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL27802807 | 0.81 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL2016174 | 0.79 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL10285585 | 0.77 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB | |
| SCHEMBL10285587 | 0.77 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3R2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513109-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-06-23 | — | — | WO | disclosed |