Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.43 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14690773 | 0.99 | MEN1 (0.43) | MEN1KMT2AKDM4EALOX15MAPT | |
| SCHEMBL14690826 | 0.83 | ABCG2 (0.52) | MEN1KMT2AKDM4EMAPTCYP3A4 | |
| SCHEMBL14692501 | 0.81 | MEN1 (0.51) | MEN1KMT2AKDM4EALOX15MAPT | |
| SCHEMBL14691177 | 0.81 | KDM4E (0.51) | MEN1KMT2AKDM4EALOX15MAPT | |
| SCHEMBL20496408 | 0.78 | KDM4E (0.46) | MEN1KMT2AKDM4EALOX15MAPT | |
| Bromide SCHEMBL20496404 | 0.77 | GRIN2D (0.44) | MEN1KMT2AKDM4EALOX15MAPT | |
| SCHEMBL14690620 | 0.76 | NR1I2 (0.47) | MEN1KMT2AKDM4EALOX15MAPT | |
| SCHEMBL14691200 | 0.75 | GRIN2D (0.45) | MEN1KMT2AKDM4EALOX15MAPT | |
| Bromide SCHEMBL20496407 | 0.74 | NR1I2 (0.52) | MEN1KMT2AKDM4EALOX15MAPT | |
| SCHEMBL311798 | 0.74 | KDM4E (0.51) | MEN1KMT2AKDM4EALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742033-B1 | FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF | ARMARON BIO PTY LTD (AU) | 2018-09-19 | — | — | EP | claimed |