Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2502760 | 1.00 | SYK (0.76) | SYK | |
| SCHEMBL2049981 | 1.00 | SYK (0.76) | SYK | |
| SCHEMBL2498779 | 1.00 | SYK (0.76) | SYK | |
| SCHEMBL2049980 | 1.00 | SYK (0.76) | SYK | |
| SCHEMBL2506428 | 1.00 | SYK (0.76) | SYK | |
| SCHEMBL2519221 | 1.00 | SYK (0.76) | SYK | |
| SCHEMBL2500468 | 0.95 | SYK (0.74) | SYK | |
| SCHEMBL2500475 | 0.95 | SYK (0.74) | SYK | |
| SCHEMBL2500471 | 0.95 | SYK (0.74) | SYK | |
| SCHEMBL13518136 | 0.93 | SYK (0.82) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |