Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20501241 | 1.00 | CRBN (0.50) | CRBNCSNK1A1IKZF2IKZF1IKZF3 | |
| SCHEMBL20496835 | 0.85 | CRBN (0.57) | CRBNCSNK1A1IKZF2MAP1LC3B | |
| SCHEMBL20496837 | 0.85 | CRBN (0.57) | CRBNCSNK1A1IKZF2MAP1LC3B | |
| SCHEMBL20501230 | 0.82 | CRBN (0.57) | CRBNIKZF2IKZF1IKZF3MAP1LC3B | |
| SCHEMBL20501229 | 0.82 | CRBN (0.57) | CRBNIKZF2IKZF1IKZF3MAP1LC3B | |
| SCHEMBL25874412 | 0.81 | CRBN (0.56) | CRBNIKZF2IKZF3AKR1B10AKR1B1 | |
| SCHEMBL31305189 | 0.80 | CRBN (0.57) | CRBNCSNK1A1IKZF2IKZF3GSPT1 | |
| SCHEMBL31305140 | 0.79 | CRBN (0.58) | CRBNCSNK1A1IKZF2IKZF1IKZF3 | |
| SCHEMBL29521599 | 0.79 | CRBN (0.58) | CRBNCSNK1A1IKZF2IKZF1IKZF3 | |
| SCHEMBL23561213 | 0.78 | CRBN (0.61) | CRBNCSNK1A1IKZF2IKZF1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018169777-A1 | COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. (US) | 2018-09-20 | — | — | WO | disclosed |