Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CPT1A | P50416 | 5/20 | 0.53 |
| ▸ | CPT2 | P23786 | 2/20 | 0.53 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951889 | 0.85 | GRM5 (0.55) | GRM5NPC1RAB9AL3MBTL1CPT1A | |
| SCHEMBL1951891 | 0.85 | GRM5 (0.55) | GRM5NPC1RAB9AL3MBTL1CPT1A | |
| SCHEMBL14061485 | 0.84 | GRM5 (0.54) | GRM5CPT1AHCRTR1HCRTR2 | |
| SCHEMBL14061487 | 0.82 | CPT1A (0.55) | GRM5CPT1ACPT2CPT1BHCRTR1 | |
| SCHEMBL17654719 | 0.82 | CPT1A (0.53) | GRM5CPT1A | |
| SCHEMBL17654721 | 0.82 | CPT1A (0.53) | GRM5CPT1A | |
| SCHEMBL17654626 | 0.82 | NR1H4 (0.60) | GRM5CPT1ACPT2CPT1BNR1H4 | |
| SCHEMBL17654623 | 0.82 | NR1H4 (0.60) | GRM5CPT1ACPT2CPT1BNR1H4 | |
| SCHEMBL15176171 | 0.82 | CPT1A (0.57) | GRM5CPT1ACPT2CPT1BHCRTR1 | |
| SCHEMBL15175291 | 0.81 | HCRTR1 (0.57) | GRM5CPT1ACPT2CPT1BHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162635-A1 | METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2012-11-29 | — | — | WO | disclosed |
| WO-2011068941-A2 | PROLINE DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-06-09 | — | — | WO | disclosed |