Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 15/20 | 0.51 |
| ▸ | JAK1 | P23458 | 10/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | LTK | P29376 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CLK2 | P49760 | 2/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29540818 | 1.00 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL100175 | 1.00 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL98943 | 1.00 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL29541025 | 1.00 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL29540688 | 0.94 | TYRO3 (0.50) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL100597 | 0.94 | TYRO3 (0.50) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL22584068 | 0.93 | TYRO3 (0.49) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL100563 | 0.93 | TYRO3 (0.55) | TYRO3JAK2JAK1JAK3TYK2 | |
| SCHEMBL2144942 | 0.92 | JAK2 (0.59) | TYRO3JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL99485 | 0.91 | JAK2 (0.52) | TYRO3JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |
| EP-3184526-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2018-10-03 | — | — | EP | disclosed |