Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.87 |
| ▸ | MEN1 | O00255 | 6/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.87 |
| ▸ | POLB | P06746 | 3/20 | 0.87 |
| ▸ | RECQL | P46063 | 2/20 | 0.87 |
| ▸ | NPC1 | O15118 | 1/20 | 0.87 |
| ▸ | THRB | P10828 | 1/20 | 0.87 |
| ▸ | RAB9A | P51151 | 1/20 | 0.87 |
| ▸ | ATM | Q13315 | 1/20 | 0.87 |
| ▸ | COMT | P21964 | 2/20 | 0.84 |
| ▸ | MMP2 | P08253 | 1/20 | 0.81 |
| ▸ | MMP9 | P14780 | 1/20 | 0.81 |
| ▸ | MMP8 | P22894 | 1/20 | 0.81 |
| ▸ | MMP13 | P45452 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 5/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31578829 | 0.93 | MAPT (1.00) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL2582594 | 0.93 | MAPT (1.00) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL25215586 | 0.90 | COMT (0.80) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL30445900 | 0.90 | COMT (0.80) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL2250333 | 0.90 | COMT (1.00) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL17498803 | 0.89 | MAPT (0.91) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL17498773 | 0.88 | MAPT (0.85) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL12113071 | 0.88 | MAPT (0.89) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL16147976 | 0.84 | MAPT (0.78) | MAPTKMT2AMEN1KDM4EPOLB | |
| SCHEMBL12010985 | 0.84 | COMT (0.83) | MAPTKMT2AMEN1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3381906-A1 | COMPOUNDS FOR USE AS HEPARANASE INHIBITORS | Leadiant Biosciences SA (CH) | 2018-10-03 | — | — | EP | claimed |