Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.52 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16876286 | 1.00 | SYK (0.52) | SYKIDH2 | |
| SCHEMBL16876406 | 0.91 | SYK (0.53) | SYK | |
| SCHEMBL16876058 | 0.91 | SYK (0.53) | SYK | |
| SCHEMBL16876314 | 0.91 | SYK (0.53) | SYK | |
| SCHEMBL16876402 | 0.88 | SYK (0.61) | SYK | |
| SCHEMBL20514628 | 0.88 | SYK (0.61) | SYK | |
| SCHEMBL16876136 | 0.81 | SYK (0.54) | SYK | |
| SCHEMBL16876137 | 0.81 | SYK (0.54) | SYK | |
| SCHEMBL16876257 | 0.81 | SYK (0.54) | SYK | |
| SCHEMBL16876381 | 0.80 | SYK (0.48) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2863914-B1 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-10-03 | — | — | EP | disclosed |