Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 10/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037534 | 0.90 | EIF2AK4 (0.40) | EIF2AK4ADORA2AJAK2JAK1JAK3 | |
| SCHEMBL2037539 | 0.90 | EIF2AK4 (0.40) | EIF2AK4ADORA2AJAK2JAK1JAK3 | |
| SCHEMBL12611068 | 0.87 | EIF2AK4 (0.45) | EIF2AK4ADORA2AJAK2JAK1JAK3 | |
| SCHEMBL2039830 | 0.86 | MC4R (0.46) | EIF2AK4JAK2JAK1JAK3MC4R | |
| SCHEMBL2039828 | 0.86 | MC4R (0.46) | EIF2AK4JAK2JAK1JAK3MC4R | |
| SCHEMBL2033313 | 0.86 | JAK2 (0.43) | EIF2AK4JAK2JAK1JAK3RAB9A | |
| SCHEMBL2033315 | 0.86 | JAK2 (0.43) | EIF2AK4JAK2JAK1JAK3RAB9A | |
| SCHEMBL2002185 | 0.85 | EIF2AK4 (0.47) | EIF2AK4JAK2JAK1JAK3 | |
| SCHEMBL2040116 | 0.85 | EIF2AK4 (0.47) | EIF2AK4JAK2JAK1JAK3FLT3 | |
| SCHEMBL2040117 | 0.85 | EIF2AK4 (0.47) | EIF2AK4JAK2JAK1JAK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | claimed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | claimed |
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |