Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 8/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.46 |
| ▸ | BAD | Q92934 | 6/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 12/20 | 0.39 |
| ▸ | PMAIP1 | Q13794 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521826 | 0.88 | BCL2 (0.45) | BCL2BCL2L1BADMCL1PMAIP1 | |
| SCHEMBL20522054 | 0.87 | BCL2 (0.47) | BCL2BCL2L1BADMCL1PMAIP1 | |
| SCHEMBL20521541 | 0.84 | BCL2L1 (0.46) | BCL2BCL2L1BADMCL1PMAIP1 | |
| SCHEMBL24415765 | 0.80 | BCL2 (0.42) | BCL2BCL2L1BADMCL1 | |
| SCHEMBL20521958 | 0.79 | BCL2 (0.46) | BCL2BCL2L1BADMCL1PMAIP1 | |
| SCHEMBL20521806 | 0.78 | BAD (0.42) | BCL2BCL2L1BAD | |
| SCHEMBL30000640 | 0.75 | BCL2 (0.75) | BCL2BCL2L1MCL1 | |
| SCHEMBL17113159 | 0.75 | BCL2 (0.75) | BCL2BCL2L1MCL1 | |
| SCHEMBL20521654 | 0.74 | BCL2L1 (0.45) | BCL2BCL2L1BADMCL1PMAIP1 | |
| SCHEMBL20521693 | 0.74 | BCL2 (0.44) | BCL2BCL2L1BADMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018178226-A1 | MCL-1 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2018-10-04 | — | — | WO | disclosed |