Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053451 | 0.89 | POLB (0.51) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL9994908 | 0.88 | GRM5 (0.46) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL6922080 | 0.86 | POLB (0.48) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL2053790 | 0.86 | POLB (0.48) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL2047709 | 0.85 | POLB (0.50) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL2052744 | 0.84 | POLB (0.46) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL2053242 | 0.80 | POLB (0.49) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL2051272 | 0.80 | POLB (0.49) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL2052100 | 0.80 | POLB (0.49) | POLBPTPN7DUSP3RXFP1NPC1 | |
| SCHEMBL6922468 | 0.76 | POLB (0.46) | POLBPTPN7DUSP3RXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |