Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.58 |
| ▸ | WNT3A | P56704 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9436940 | 0.88 | MEN1 (0.57) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL24443509 | 0.81 | MEN1 (0.53) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL9436983 | 0.80 | HPGD (0.53) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL1092123 | 0.78 | ATM (0.81) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL29639737 | 0.78 | ATM (0.81) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL15969068 | 0.78 | CTNNB1 (0.64) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL29458253 | 0.77 | MEN1 (0.76) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL2237626 | 0.77 | MEN1 (0.76) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL109220 | 0.77 | HPGD (0.70) | HPGDCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL5381632 | 0.76 | MEN1 (0.69) | HPGDCTNNB1WNT3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601232-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES | Curza Global LLC (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018184019-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES | CURZA GLOBAL, LLC (US) | 2018-10-04 | — | — | WO | disclosed |