Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21724299 | 0.86 | MAP3K5 (0.42) | POLBTDP1KMT2AATML3MBTL1 | |
| SCHEMBL20524692 | 0.85 | MAPT (0.39) | KMT2AL3MBTL1ALDH1A1LMNAMAP3K5 | |
| SCHEMBL22712271 | 0.85 | POLB (0.40) | POLBTDP1KMT2AATML3MBTL1 | |
| SCHEMBL21723855 | 0.82 | MAP3K5 (0.45) | POLBTDP1KMT2AALDH1A1MAP3K5 | |
| SCHEMBL20524617 | 0.82 | KMT2A (0.42) | POLBTDP1KMT2AATML3MBTL1 | |
| SCHEMBL21723813 | 0.81 | KMT2A (0.38) | POLBTDP1KMT2AATML3MBTL1 | |
| SCHEMBL21724079 | 0.81 | MAP3K5 (0.44) | POLBTDP1KMT2AATML3MBTL1 | |
| SCHEMBL21723853 | 0.81 | MAP3K5 (0.45) | POLBTDP1KMT2AL3MBTL1MAP3K5 | |
| SCHEMBL2516540 | 0.80 | POLB (0.44) | POLBTDP1KMT2AATML3MBTL1 | |
| SCHEMBL21723833 | 0.80 | KMT2A (0.41) | POLBTDP1KMT2AATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |