Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2507970 | 0.82 | SYK (0.65) | SYK | |
| SCHEMBL16737301 | 0.74 | SYK (0.65) | SYK | |
| SCHEMBL17006666 | 0.74 | SYK (1.00) | SYK | |
| SCHEMBL20377596 | 0.74 | SYK (0.61) | SYK | |
| SCHEMBL2501936 | 0.74 | SYK (0.62) | SYK | |
| SCHEMBL16737907 | 0.73 | SYK (0.58) | SYK | |
| SCHEMBL2016932 | 0.72 | SYK (0.63) | SYK | |
| SCHEMBL2499758 | 0.72 | SYK (0.67) | SYK | |
| SCHEMBL2040654 | 0.72 | SYK (0.60) | SYK | |
| SCHEMBL16737851 | 0.71 | SYK (0.60) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |