Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17823254 | 0.82 | MAP4K4 (0.41) | MAP4K4PDE10A | |
| SCHEMBL17827964 | 0.71 | — | — | |
| SCHEMBL19677558 | 0.69 | MAP4K4 (0.47) | MAP4K4PDE10ASUV39H2 | |
| SCHEMBL19665197 | 0.69 | MAP4K4 (0.47) | MAP4K4PDE10ASUV39H2 | |
| SCHEMBL2738166 | 0.68 | TP53 (0.35) | SUV39H2 | |
| SCHEMBL19665199 | 0.68 | PDE10A (0.43) | MAP4K4PDE10A | |
| SCHEMBL19677561 | 0.68 | PDE10A (0.43) | MAP4K4PDE10A | |
| SCHEMBL17827967 | 0.66 | SUV39H2 (0.38) | MAP4K4PDE10AJAK3BTKSUV39H2 | |
| SCHEMBL17823232 | 0.66 | — | — | |
| SCHEMBL2738131 | 0.66 | TRPV1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230287-B1 | PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | JANSSEN SCIENCES IRELAND UC (IE) | 2018-10-10 | — | — | EP | disclosed |