Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 1.00 |
| ▸ | JAK2 | O60674 | 14/20 | 0.84 |
| ▸ | JAK1 | P23458 | 1/20 | 0.84 |
| ▸ | TYK2 | P29597 | 1/20 | 0.84 |
| ▸ | JAK3 | P52333 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14716903 | 1.00 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717214 | 0.92 | SYK (0.89) | SYKJAK2JAK1TYK2JAK3 | |
| Gusacitinib SCHEMBL29467492 | 0.91 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| Gusacitinib SCHEMBL14717111 | 0.91 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| Gusacitinib SCHEMBL25373888 | 0.90 | SYK (0.98) | SYKJAK2JAK1TYK2JAK3 | |
| Gusacitinib SCHEMBL31038820 | 0.90 | SYK (0.98) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14716799 | 0.90 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL22101952 | 0.90 | SYK (0.93) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL20529577 | 0.90 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL20529578 | 0.90 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018187294-A1 | PYRIMIDO-PYRIDAZINONE COMPOUND COMBINATIONS, METHODS, KITS AND FORMULATIONS THEREOF | ASANA BIOSCIENCES, LLC (US) | 2018-10-11 | — | — | WO | claimed |