Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.64 |
| ▸ | LCK | P06239 | 16/20 | 0.58 |
| ▸ | HCK | P08631 | 5/20 | 0.57 |
| ▸ | BTK | Q06187 | 3/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | YES1 | P07947 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | FGR | P09769 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530773 | 1.00 | MAPK14 (0.64) | MAPK14LCKHCKBTKMAPK13 | |
| SCHEMBL20530733 | 0.89 | MAPK14 (0.60) | MAPK14LCKHCKBTKMAPK13 | |
| SCHEMBL20530734 | 0.89 | MAPK14 (0.60) | MAPK14LCKHCKBTKMAPK13 | |
| SCHEMBL20530737 | 0.83 | MAPK14 (0.67) | MAPK14LCKHCKMAPK13EGFR | |
| SCHEMBL20530738 | 0.83 | MAPK14 (0.67) | MAPK14LCKHCKMAPK13EGFR | |
| SCHEMBL20530786 | 0.82 | MAPK14 (0.58) | MAPK14LCKHCKBTKMAPK13 | |
| SCHEMBL20530781 | 0.82 | MAPK14 (0.58) | MAPK14LCKHCKBTKMAPK13 | |
| SCHEMBL20530749 | 0.82 | MAPK14 (0.69) | MAPK14LCKHCKMAPK13EGFR | |
| SCHEMBL20530772 | 0.81 | MAPK14 (0.63) | MAPK14LCKHCKBTKMAPK13 | |
| SCHEMBL20530743 | 0.81 | MAPK14 (0.76) | MAPK14LCKHCKMAPK13EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388430-A1 | COMPOUND, COMPOUND FOR USE IN THE TREATMENT OF A PATHOLOGICAL CONDITION, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR PREPARING SAID COMPOUND | Technische Universität München (DE) | 2018-10-17 | — | — | EP | disclosed |