SCHEMBL20532111

SCHEMBL20532111

Cn1cc(-c2cnn(Cc3cccc(C#N)c3)c2)ccc1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 16/20 1.00
ALK Q9UM73 1/20 0.53
KLKB1 P03952 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
MET P08581 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30770288 1.00 CREBBP (1.00) CREBBPALKKLKB1L3MBTL1MET
SCHEMBL20532189 0.82 CREBBP (1.00) CREBBPL3MBTL1
SCHEMBL20532295 0.77 CREBBP (1.00) CREBBP
SCHEMBL20532419 0.76 CREBBP (0.69) CREBBP
SCHEMBL18232748 0.76 CREBBP (0.60) CREBBPALKKLKB1
SCHEMBL20532278 0.75 CREBBP (1.00) CREBBPALKL3MBTL1
SCHEMBL20532073 0.75 CREBBP (1.00) CREBBP
SCHEMBL30770310 0.75 CREBBP (1.00) CREBBP
SCHEMBL19116683 0.74 CREBBP (0.59) CREBBPALKKLKB1L3MBTL1
SCHEMBL3918666 0.74 GRM5 (0.62) CREBBPALKL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240293381-A1 Therapeutic Compounds CELGENE QUANTICEL RES INC (US) 2024-09-05 US claimed
US-11020380-B2 Therapeutic compounds CELGENE QUANTICEL RESEARCH, INC. (US) 2021-06-01 US claimed
US-20200163946-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. (US) 2020-05-28 US claimed
US-20180296543-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. 2018-10-18 US claimed
US-20240293381-A1 Therapeutic Compounds CELGENE QUANTICEL RES INC (US) 2024-09-05 US disclosed
US-11890275-B2 Therapeutic compounds CELGENE QUANTICEL RESEARCH, INC. 2024-02-06 US disclosed
US-20210205284-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. (US) 2021-07-08 US disclosed
US-20210205284-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. (US) 2021-07-08 US disclosed
US-11020380-B2 Therapeutic compounds CELGENE QUANTICEL RESEARCH, INC. (US) 2021-06-01 US disclosed
US-11020380-B2 Therapeutic compounds CELGENE QUANTICEL RESEARCH, INC. (US) 2021-06-01 US disclosed
US-20200163946-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. (US) 2020-05-28 US disclosed
US-20200163946-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. (US) 2020-05-28 US disclosed
US-10617680-B2 Therapeutic compounds CELGENE QUANTICEL RESEARCH, INC. (US) 2020-04-14 US disclosed
US-10617680-B2 Therapeutic compounds CELGENE QUANTICEL RESEARCH, INC. (US) 2020-04-14 US disclosed
US-20180296543-A1 THERAPEUTIC COMPOUNDS CELGENE QUANTICEL RESEARCH, INC. 2018-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11020380-B2 Therapeutic compounds EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885
US-20240293381-A1 Therapeutic Compounds EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885
US-20200163946-A1 THERAPEUTIC COMPOUNDS EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885
US-20180296543-A1 THERAPEUTIC COMPOUNDS EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885
US-20210205284-A1 THERAPEUTIC COMPOUNDS EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885
US-10617680-B2 Therapeutic compounds EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885
US-11890275-B2 Therapeutic compounds EP300, BRD4, BRD3 CREBBP 18/4885ALK 2680/4885KLKB1 4268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.