Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 1.00 |
| ▸ | PGRMC1 | O00264 | 1/20 | 0.86 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.86 |
| ▸ | CDK4 | P11802 | 1/20 | 0.86 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.86 |
| ▸ | CCKBR | P32239 | 1/20 | 0.86 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.86 |
| ▸ | HTR2B | P41595 | 1/20 | 0.86 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.86 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.86 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.86 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.86 |
| ▸ | PCYT1A | P49585 | 1/20 | 0.86 |
| ▸ | GSK3A | P49840 | 1/20 | 0.86 |
| ▸ | GSK3B | P49841 | 1/20 | 0.86 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.86 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.86 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240787 | 1.00 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| SCHEMBL8232230 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| SCHEMBL20532258 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| Encorafenib SCHEMBL31210316 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| Encorafenib SCHEMBL8228295 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| Encorafenib SCHEMBL8231398 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| Encorafenib SCHEMBL29368575 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| Encorafenib SCHEMBL8512458 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| SCHEMBL8237686 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 | |
| SCHEMBL30356458 | 0.93 | BRAF (1.00) | BRAFPGRMC1RIPK2NR1I2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10568884-B2 | Compounds and compositions as protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-02-25 | — | — | US | disclosed |
| US-20180297986-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2018-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10568884-B2 | Compounds and compositions as protein kinase inhibitors | BRAF, RAF1, ARAF | BRAF 1/4885PGRMC1 3549/4885RIPK2 384/4885 |
| US-20180297986-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | BRAF, RAF1, ARAF | BRAF 1/4885PGRMC1 3549/4885RIPK2 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.