Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017026 | 0.96 | PIK3CD (0.44) | PIK3CDLMNAMAPTALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2054376 | 0.92 | PIK3CD (0.41) | PIK3CDMAPTL3MBTL1NPY2RGPR6 | |
| Trifluoroacetic Acid SCHEMBL2052614 | 0.91 | PIK3CD (0.40) | PIK3CDLMNAMAPTALDH1A1L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2163822 | 0.90 | PIK3CD (0.43) | PIK3CDALDH1A1L3MBTL1KDM4ENPY2R | |
| Trifluoroacetic Acid SCHEMBL2053153 | 0.90 | PIK3CD (0.41) | PIK3CDSMN1; SMN2L3MBTL1GPR6NPC1 | |
| Trifluoroacetic Acid SCHEMBL2054020 | 0.89 | PIK3CD (0.47) | PIK3CDMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2164857 | 0.88 | PIK3CD (0.42) | PIK3CDMAPTL3MBTL1KDM4EGPR6 | |
| Trifluoroacetic Acid SCHEMBL2036109 | 0.88 | PIK3CD (0.42) | PIK3CDMAPTALDH1A1L3MBTL1KDM4E | |
| Trifluoroacetic Acid SCHEMBL2054305 | 0.88 | PIK3CD (0.40) | PIK3CDLMNAMAPTALDH1A1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2054306 | 0.87 | PIK3CD (0.39) | PIK3CDALDH1A1SMN1; SMN2L3MBTL1GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680108-B2 | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-07-28 | — | — | US | disclosed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | PIK3R1, PIK3R3, PIK3R2 | PIK3CD 13/4885LMNA 4440/4885MAPT 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.