Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23316896 | 0.89 | HDAC6 (0.54) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL20535197 | 0.80 | HDAC6 (0.58) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL29640377 | 0.77 | HDAC6 (0.56) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL23316897 | 0.77 | HDAC6 (0.56) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL20534974 | 0.74 | HDAC6 (0.77) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL20534700 | 0.74 | HDAC6 (0.66) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Trifluoroacetic Acid SCHEMBL20535170 | 0.72 | HDAC6 (0.51) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL20534784 | 0.72 | HDAC6 (0.67) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL23316860 | 0.70 | HDAC6 (0.68) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL20535764 | 0.70 | HDAC6 (0.66) | HDAC6HDAC1HDAC3HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562810-B1 | BENZHYDROXAMIC ACID DERIVATIVES AS SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-05-03 | — | — | EP | claimed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | claimed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | claimed |
| EP-3562810-A1 | SELECTIVE HDAC6 INHIBITORS | Italfarmaco SpA (IT) | 2019-11-06 | — | — | EP | claimed |
| WO-2018189340-A1 | SELECTIVE HDAC6 INHIBITORS | ITALFARMACO S.P.A. (IT) | 2018-10-18 | — | — | WO | claimed |
| EP-3562810-B1 | BENZHYDROXAMIC ACID DERIVATIVES AS SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-05-03 | — | — | EP | disclosed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
| EP-3562810-A1 | SELECTIVE HDAC6 INHIBITORS | Italfarmaco SpA (IT) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018189340-A1 | SELECTIVE HDAC6 INHIBITORS | ITALFARMACO S.P.A. (IT) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128577-A1 | Selective HDAC6 Inhibitors | HDAC6, HDAC1, HDAC3 | HDAC6 1/4885HDAC1 2/4885HDAC3 3/4885 |
| US-11351178-B2 | Selective HDAC6 inhibitors | HDAC6, HDAC1, HDAC3 | HDAC6 1/4885HDAC1 2/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.