Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2054114 | 0.98 | PIK3CD (0.40) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| Trifluoroacetic Acid SCHEMBL2163475 | 0.97 | PIK3CD (0.42) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| Trifluoroacetic Acid SCHEMBL2163349 | 0.94 | PIK3CD (0.40) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| SCHEMBL2017826 | 0.93 | PIK3CD (0.44) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| Trifluoroacetic Acid SCHEMBL2054109 | 0.91 | PIK3CD (0.43) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| SCHEMBL2017405 | 0.91 | PIK3CD (0.43) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| Trifluoroacetic Acid SCHEMBL2054412 | 0.90 | PIK3CD (0.40) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| SCHEMBL2013639 | 0.90 | PIK3CD (0.45) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| Trifluoroacetic Acid SCHEMBL2052514 | 0.89 | PIK3CD (0.41) | PIK3CDL3MBTL1NPC1RAB9AALOX12 | |
| Trifluoroacetic Acid SCHEMBL2038413 | 0.88 | PIK3CD (0.41) | PIK3CDL3MBTL1NPC1RAB9AALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680108-B2 | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-07-28 | — | — | US | disclosed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | PIK3R1, PIK3R3, PIK3R2 | PIK3CD 13/4885L3MBTL1 2960/4885NPC1 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.