Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16810826 | 0.72 | TDP1 (0.54) | TDP1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL31459666 | 0.70 | TDP1 (0.38) | TDP1MEN1KMT2ANPSR1HTT | |
| SCHEMBL20535986 | 0.69 | RHEB (0.67) | TDP1MEN1KMT2ANPSR1RHEB | |
| SCHEMBL20535497 | 0.69 | RHEB (0.67) | TDP1MEN1KMT2ARHEB | |
| SCHEMBL20536755 | 0.69 | RHEB (0.52) | TDP1RHEBHTT | |
| SCHEMBL22333123 | 0.69 | TDP1 (0.40) | TDP1KMT2ANPSR1 | |
| SCHEMBL31569117 | 0.69 | KDM4E (0.41) | TDP1KDM4EMEN1KMT2A | |
| SCHEMBL29467211 | 0.68 | KDM4E (0.60) | KDM4E | |
| SCHEMBL23709609 | 0.67 | RHEB (0.51) | KDM4ERHEB | |
| SCHEMBL25369555 | 0.66 | TDP1 (0.47) | TDP1KDM4EMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |