Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | CDC42 | P60953 | 1/20 | 0.48 |
| ▸ | RB1 | P06400 | 5/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149725 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL4194153 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL4199294 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL5461901 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL4195673 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL4194377 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL4172408 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| SCHEMBL20537338 | 1.00 | CYP2D6 (0.78) | CYP2D6KCNH2GAACASP6PRMT5 | |
| Hydrochloric Acid SCHEMBL4152184 | 0.99 | CYP2D6 (0.77) | CYP2D6KCNH2GAACASP6PRMT5 | |
| Hydrochloric Acid SCHEMBL4165920 | 0.99 | CYP2D6 (0.77) | CYP2D6KCNH2GAACASP6PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110914270-B | Preparation method of pirlindole enantiomer and salt thereof | 社会医疗技术员技术股份公司 | 2022-05-03 | — | — | CN | claimed |
| CN-110831943-B | Method for producing piperazine rings for the synthesis of pyrazinocarbazole derivatives | 社会医疗技术员技术股份公司 | 2022-05-03 | — | — | CN | claimed |
| EP-3612534-B1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE SOCIEDADE TECNICO MEDICINAL SA (PT) | 2021-12-22 | — | — | EP | claimed |
| US-20200190098-A1 | PROCESS FOR THE PREPARATION OF PIRLINDOLE ENANTIOMERS AND ITS SALTS | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2020-06-18 | — | — | US | claimed |
| US-20200131186-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2020-04-30 | — | — | US | claimed |
| CN-110914270-A | Preparation method of pirlindole enantiomer and salt thereof | 社会医疗技术员技术股份公司 | 2020-03-24 | — | — | CN | claimed |
| CN-110831943-A | Method for producing piperazine rings for the synthesis of pyrazinocarbazole derivatives | 社会医疗技术员技术股份公司 | 2020-02-21 | — | — | CN | claimed |
| EP-3392251-A1 | PROCESS FOR THE PREPARATION OF PIRLINDOLE ENANTIOMERS AND ITS SALTS | TECNIMEDE-SOCIEDADE TECNICO-MEDICINAL, S.A. (PT) | 2018-10-24 | — | — | EP | claimed |
| EP-3392250-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE-SOCIEDADE TECNICO-MEDICINAL, S.A. (PT) | 2018-10-24 | — | — | EP | claimed |
| CN-110914270-B | Preparation method of pirlindole enantiomer and salt thereof | 社会医疗技术员技术股份公司 | 2022-05-03 | — | — | CN | disclosed |
| CN-110831943-B | Method for producing piperazine rings for the synthesis of pyrazinocarbazole derivatives | 社会医疗技术员技术股份公司 | 2022-05-03 | — | — | CN | disclosed |
| EP-3612534-B1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE SOCIEDADE TECNICO MEDICINAL SA (PT) | 2021-12-22 | — | — | EP | disclosed |
| US-11008327-B2 | Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2021-05-18 | — | — | US | disclosed |
| US-11008328-B2 | Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2021-05-18 | — | — | US | disclosed |
| US-20200190098-A1 | PROCESS FOR THE PREPARATION OF PIRLINDOLE ENANTIOMERS AND ITS SALTS | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2020-06-18 | — | — | US | disclosed |
| US-20200131186-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA (PT) | 2020-04-30 | — | — | US | disclosed |
| CN-110914270-A | Preparation method of pirlindole enantiomer and salt thereof | 社会医疗技术员技术股份公司 | 2020-03-24 | — | — | CN | disclosed |
| CN-110831943-A | Method for producing piperazine rings for the synthesis of pyrazinocarbazole derivatives | 社会医疗技术员技术股份公司 | 2020-02-21 | — | — | CN | disclosed |
| EP-3392251-A1 | PROCESS FOR THE PREPARATION OF PIRLINDOLE ENANTIOMERS AND ITS SALTS | TECNIMEDE-SOCIEDADE TECNICO-MEDICINAL, S.A. (PT) | 2018-10-24 | — | — | EP | disclosed |
| EP-3392250-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | TECNIMEDE-SOCIEDADE TECNICO-MEDICINAL, S.A. (PT) | 2018-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190098-A1 | PROCESS FOR THE PREPARATION OF PIRLINDOLE ENANTIOMERS AND ITS SALTS | PIR, DRD1, DRD4 | CYP2D6 29/4885KCNH2 1544/4885GAA 3662/4885 |
| US-11008327-B2 | Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole | PIR, DRD5, DRD1 | CYP2D6 102/4885KCNH2 1118/4885GAA 3836/4885 |
| US-20200131186-A1 | PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES | PIR, CYP3A5, DRD5 | CYP2D6 188/4885KCNH2 523/4885GAA 4284/4885 |
| US-11008328-B2 | Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole | PIR, DRD1, DRD5 | CYP2D6 156/4885KCNH2 1899/4885GAA 3573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.