SCHEMBL20538677

SCHEMBL20538677

CC(NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)nc1)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 1.00
ALOX5AP P20292 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15918565 1.00 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916893 1.00 FEN1 (1.00) FEN1ALOX5AP
Trifluoroacetic Acid SCHEMBL15915446 0.95 FEN1 (0.90) FEN1ALOX5AP
Trifluoroacetic Acid SCHEMBL15916573 0.95 FEN1 (0.90) FEN1ALOX5AP
SCHEMBL15932371 0.84 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL20538694 0.84 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15932353 0.84 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL20538634 0.83 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916895 0.83 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15936660 0.82 FEN1 (1.00) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-10-24 EP claimed
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed