Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19287188 | 1.00 | HTR2C (0.42) | HTR2CP2RX4CA1CA2ACHE | |
| SCHEMBL1810049 | 1.00 | HTR2C (0.42) | HTR2CP2RX4CA1CA2ACHE | |
| SCHEMBL8074350 | 1.00 | HTR2C (0.42) | HTR2CP2RX4CA1CA2ACHE | |
| SCHEMBL31000581 | 0.92 | HTR2C (0.47) | HTR2CLMNAMAPTPREP | |
| SCHEMBL17996537 | 0.89 | P2RY1 (0.40) | HTR2CCA2ACHE | |
| SCHEMBL17996490 | 0.85 | PRNP (0.39) | HTR2CCA1CA2ACHE | |
| SCHEMBL2170846 | 0.83 | HSD17B2 (0.40) | ATM | |
| SCHEMBL2170851 | 0.83 | HSD17B2 (0.40) | ATM | |
| SCHEMBL17996588 | 0.80 | PDE1C (0.44) | HTR2CLMNAPREP | |
| SCHEMBL16595628 | 0.79 | PDE1C (0.49) | HTR2CLMNAPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594565-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-10-24 | — | — | EP | disclosed |