Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.71 |
| ▸ | BTK | Q06187 | 11/20 | 0.71 |
| ▸ | LCK | P06239 | 6/20 | 0.71 |
| ▸ | JAK3 | P52333 | 7/20 | 0.57 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20540850 | 1.00 | EGFR (0.71) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL20540483 | 1.00 | EGFR (0.71) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL18283679 | 0.95 | BTK (0.64) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL18283676 | 0.95 | BTK (0.64) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL18283860 | 0.95 | BTK (0.64) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL18296251 | 0.94 | BTK (0.63) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL20540776 | 0.94 | BTK (0.63) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL18296247 | 0.94 | BTK (0.63) | EGFRBTKLCKJAK3ITK | |
| SCHEMBL18283547 | 0.86 | EGFR (0.53) | EGFRBTKLCKJAK3 | |
| SCHEMBL23080659 | 0.86 | EGFR (0.62) | EGFRBTKLCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC | 2018-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | EGFR 705/4885BTK 1/4885LCK 3/4885 |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | EGFR 705/4885BTK 1/4885LCK 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.