Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.79 |
| ▸ | AXL | P30530 | 2/20 | 0.66 |
| ▸ | MERTK | Q12866 | 2/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016845 | 0.88 | PIK3CD (0.62) | PIK3CDAXLMERTKPIK3CGPIK3CB | |
| SCHEMBL2052623 | 0.78 | PIK3CD (0.61) | PIK3CDAXLMERTKPIK3CGPIK3CB | |
| SCHEMBL2014203 | 0.78 | PIK3CD (0.65) | PIK3CDAXLMERTKPIK3CGBCL2 | |
| SCHEMBL12403852 | 0.78 | PIK3CD (0.65) | PIK3CDAXLMERTKPIK3CGBCL2 | |
| SCHEMBL12403851 | 0.78 | PIK3CD (0.65) | PIK3CDAXLMERTKPIK3CGBCL2 | |
| SCHEMBL2014146 | 0.77 | PIK3CD (0.64) | PIK3CDAXLMERTKPIK3CGPIK3CB | |
| SCHEMBL12631307 | 0.77 | PIK3CD (0.64) | PIK3CDAXLMERTKPIK3CGBCL2 | |
| SCHEMBL2013331 | 0.76 | PIK3CD (0.44) | PIK3CDAXLMERTKPIK3CGBCL2 | |
| SCHEMBL2010635 | 0.76 | PIK3CD (0.44) | PIK3CDAXLMERTKBCL2 | |
| SCHEMBL2015186 | 0.76 | PIK3CD (0.79) | PIK3CDAXLMERTKPIK3CGBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |