Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GRB7 | Q14451 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20559203 | 1.00 | IDH1 (0.49) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL17603457 | 0.92 | IDH1 (0.49) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL17603383 | 0.90 | IDH1 (0.51) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL20560122 | 0.85 | IDH1 (0.49) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL20560121 | 0.85 | IDH1 (0.49) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL20559744 | 0.81 | IDH1 (0.56) | IDH1 | |
| SCHEMBL20559742 | 0.81 | IDH1 (0.56) | IDH1 | |
| SCHEMBL21112063 | 0.78 | IDH1 (0.49) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL17603484 | 0.78 | IDH1 (0.49) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A | |
| SCHEMBL21112073 | 0.78 | IDH1 (0.47) | IDH1SMN1; SMN2CYP1A2CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194375-B1 | PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2018-11-21 | — | — | EP | claimed |