Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 19/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20559861 | 0.90 | IDH1 (0.47) | IDH1 | |
| SCHEMBL20560010 | 0.88 | IDH1 (0.48) | IDH1 | |
| SCHEMBL17603398 | 0.88 | IDH1 (0.48) | IDH1 | |
| SCHEMBL20559845 | 0.86 | IDH1 (0.46) | IDH1 | |
| SCHEMBL20559733 | 0.85 | IDH1 (0.50) | IDH1 | |
| SCHEMBL17603466 | 0.85 | IDH1 (0.50) | IDH1 | |
| SCHEMBL20559763 | 0.81 | IDH1 (0.54) | IDH1 | |
| SCHEMBL20560008 | 0.81 | IDH1 (0.66) | IDH1 | |
| SCHEMBL17603536 | 0.81 | IDH1 (0.54) | IDH1 | |
| SCHEMBL17603317 | 0.81 | IDH1 (0.66) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194375-B1 | PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2018-11-21 | — | — | EP | claimed |