Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20559837 | 0.90 | IDH1 (0.47) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL20559889 | 0.87 | IDH1 (0.48) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL20559994 | 0.86 | IDH1 (0.45) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL17603523 | 0.85 | IDH1 (0.50) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL20560036 | 0.85 | IDH1 (0.50) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL17603416 | 0.84 | IDH1 (0.56) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL20559954 | 0.84 | IDH1 (0.69) | IDH1 | |
| SCHEMBL17603444 | 0.84 | IDH1 (0.69) | IDH1 | |
| SCHEMBL20559356 | 0.84 | IDH1 (0.56) | IDH1IDO1ABL1PDGFRBBCR | |
| SCHEMBL20559734 | 0.84 | IDH1 (0.52) | IDH1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194375-B1 | PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2018-11-21 | — | — | EP | claimed |