Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232020 | 0.89 | CYP3A4 (0.35) | PDE4BPTGER4MAPTKDM4ETDP2 | |
| SCHEMBL16586412 | 0.85 | MAPT (0.36) | PTGER4MAPTRAB9AKMT2AALDH1A1 | |
| SCHEMBL20299566 | 0.84 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2177649 | 0.83 | KMT2A (0.34) | PTGER4MAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL23030349 | 0.82 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL28628153 | 0.82 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL1233222 | 0.82 | CYP3A4 (0.35) | PTGER4MAPTKDM4ETDP2ALDH1A1 | |
| SCHEMBL10268586 | 0.82 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL10268604 | 0.79 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL23080105 | 0.78 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115215765-A | Preparation method of kreb polymer impurity | 湖北丽益医药科技有限公司 | 2022-10-21 | — | — | CN | claimed |
| US-10865217-B2 | Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED, R & D CENTER (IN) | 2020-12-15 | — | — | US | claimed |
| US-20200190120-A1 | PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2020-06-18 | — | — | US | claimed |
| CN-115215765-A | Preparation method of kreb polymer impurity | 湖北丽益医药科技有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-115215765-A | Preparation method of kreb polymer impurity | 湖北丽益医药科技有限公司 | 2022-10-21 | — | — | CN | disclosed |
| US-10981939-B2 | Process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (Crisaborole) | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2021-04-20 | — | — | US | disclosed |
| US-10981939-B2 | Process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (Crisaborole) | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2021-04-20 | — | — | US | disclosed |
| CN-108047261-B | Preparation method of clitorium | 苏州旺山旺水生物医药有限公司 | 2020-12-18 | — | — | CN | disclosed |
| CN-108047261-B | Preparation method of clitorium | 苏州旺山旺水生物医药有限公司 | 2020-12-18 | — | — | CN | disclosed |
| US-10865217-B2 | Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED, R & D CENTER (IN) | 2020-12-15 | — | — | US | disclosed |
| US-10865217-B2 | Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED, R & D CENTER (IN) | 2020-12-15 | — | — | US | disclosed |
| US-20200190120-A1 | PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2020-06-18 | — | — | US | disclosed |
| US-20200190120-A1 | PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2020-06-18 | — | — | US | disclosed |
| US-20200062785-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-[(1-HYDROXY-1,3-DIHYDRO-2,1-BENZOXABOROL-5-YL) OXY] BENZONITRILE (CRISABOROLE) | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD., (IN) | 2020-02-27 | — | — | US | disclosed |
| US-20200062785-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-[(1-HYDROXY-1,3-DIHYDRO-2,1-BENZOXABOROL-5-YL) OXY] BENZONITRILE (CRISABOROLE) | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD., (IN) | 2020-02-27 | — | — | US | disclosed |
| WO-2018216032-A1 | PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10865217-B2 | Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof | CYP1B1, CYP4B1, CYP1A1 | PDE4B 2000/4885PDE4A 2884/4885PDE4C 3873/4885 |
| US-20200062785-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-[(1-HYDROXY-1,3-DIHYDRO-2,1-BENZOXABOROL-5-YL) OXY] BENZONITRILE (CRISABOROLE) | CYP4B1, CYP8B1, CYP4X1 | PDE4B 1419/4885PDE4A 3530/4885PDE4C 3432/4885 |
| US-20200190120-A1 | PROCESS FOR THE PREPARATION OF 5-(4-CYANOPHENOXY)-1,3-DIHYDRO-1-HYDROXY-[2,1]-BENZOXABOROLE AND POLYMORPHS THEREOF | CYP1B1, CYP4B1, CYP1A1 | PDE4B 2000/4885PDE4A 2884/4885PDE4C 3873/4885 |
| US-10981939-B2 | Process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (Crisaborole) | CYP4B1, CYP8B1, SQLE | PDE4B 1665/4885PDE4A 3744/4885PDE4C 3658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.