Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 7/20 | 0.52 |
| ▸ | SRC | P12931 | 6/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.52 |
| ▸ | BCR | P11274 | 3/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | FES | P07332 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20569261 | 0.93 | ABL1 (0.60) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL20569927 | 0.88 | ABL1 (0.61) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL20569149 | 0.86 | KDR (0.56) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL25290769 | 0.81 | KDR (0.60) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL29958941 | 0.81 | KDR (0.60) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL20568621 | 0.79 | KDR (0.63) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL29186424 | 0.79 | SRC (0.76) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL20569489 | 0.78 | ABL1 (0.65) | RETKDRBRAFRAF1ABL1 | |
| SCHEMBL20569643 | 0.77 | MAPK14 (0.71) | RAF1ABL1SRCMAPK14MAP3K7 | |
| SCHEMBL25251075 | 0.77 | FGFR4 (0.58) | RETKDRBRAFRAF1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |