Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 9/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 9/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.60 |
| ▸ | FES | P07332 | 4/20 | 0.60 |
| ▸ | FER | P16591 | 4/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.60 |
| ▸ | NR2C2 | P49116 | 10/20 | 0.58 |
| ▸ | HCK | P08631 | 9/20 | 0.58 |
| ▸ | GCK | P35557 | 3/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSK | P41240 | 1/20 | 0.55 |
| ▸ | ABL2 | P42684 | 1/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20569441 | 0.97 | MAP3K7 (0.56) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568747 | 0.95 | MAP3K7 (0.54) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568097 | 0.95 | MAP3K7 (0.59) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568423 | 0.95 | ABL1 (0.54) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568314 | 0.94 | MAP3K7 (0.52) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20571973 | 0.94 | MAP3K7 (0.52) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568763 | 0.94 | MAP3K7 (0.62) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568395 | 0.93 | MAP3K7 (0.54) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568642 | 0.93 | MAP3K7 (0.52) | MAP3K7MAP4K2MAPK14FESFER | |
| SCHEMBL20568192 | 0.93 | RET (0.55) | MAP3K7MAP4K2MAPK14FESFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |