Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 9/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | LDLR | P01130 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSK | P41240 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568526 | 1.00 | MAP4K2 (0.49) | MAP4K2MAP3K7CSF1RBRAFKDR | |
| SCHEMBL20568115 | 0.92 | MAP4K2 (0.54) | MAP4K2MAP3K7CSF1RBRAFKDR | |
| SCHEMBL20568117 | 0.92 | MAP4K2 (0.54) | MAP4K2MAP3K7CSF1RBRAFKDR | |
| SCHEMBL20568959 | 0.88 | MAP4K2 (0.55) | MAP4K2MAP3K7CSF1RBRAFKDR | |
| SCHEMBL20570160 | 0.88 | MAP4K2 (0.63) | MAP4K2MAP3K7CSF1RBRAFKIT | |
| SCHEMBL20568290 | 0.86 | MAP4K2 (0.53) | MAP4K2MAP3K7CSF1RBRAFKIT | |
| SCHEMBL20569395 | 0.86 | MAP4K2 (0.54) | MAP4K2MAP3K7BRAFKITLDLR | |
| SCHEMBL20569165 | 0.84 | BRAF (0.46) | MAP4K2MAP3K7CSF1RBRAFKDR | |
| SCHEMBL20569396 | 0.84 | BRAF (0.46) | MAP4K2MAP3K7CSF1RBRAFKDR | |
| SCHEMBL20567971 | 0.84 | MAP4K2 (0.62) | MAP4K2MAP3K7CSF1RBRAFKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |