SCHEMBL20568611

SCHEMBL20568611

Cn1c(=O)cc(Cl)c2cc([N+](=O)[O-])ccc21

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.57
F2RL3 Q96RI0 4/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
LMNA P02545 2/20 0.46
F2R P25116 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HSD17B10 Q99714 1/20 0.46
L3MBTL1 Q9Y468 3/20 0.44
CYP1A2 P05177 1/20 0.43
CYP19A1 P11511 1/20 0.43
EGFR P00533 1/20 0.42
SRC P12931 1/20 0.42
POLB P06746 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31169742 1.00 MAPT (0.57) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL17576255 0.83 MAPT (0.63) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL20183779 0.81 MAPT (0.60) MAPTMEN1KMT2ALMNANPSR1
SCHEMBL30600488 0.80 MAPT (0.83) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL155568 0.80 MAPT (0.83) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL6077993 0.79 MAPT (0.55) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL29027035 0.78 MAPT (0.53) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL20568458 0.77 MAPT (0.52) MAPTF2RL3MEN1KMT2ALMNA
SCHEMBL20568859 0.77 MAPT (0.43) MAPTMEN1KMT2ALMNASMN1; SMN2
SCHEMBL23610702 0.76 MAPT (0.51) MAPTF2RL3MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4729127-A2 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2026-04-22 EP disclosed
US-20260042776-A1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2026-02-12 US disclosed
US-12486285-B2 BCL6 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2025-12-02 US disclosed
EP-3630749-B9 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 EP disclosed
EP-4371562-A2 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2024-05-22 EP disclosed
EP-3630749-B1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-01-10 EP disclosed
US-20230287003-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-14 US disclosed
US-20230287003-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-14 US disclosed
US-20230287003-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2023-09-14 US disclosed
EP-4201939-A1 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2023-06-28 EP disclosed
US-11161839-B2 2-quinolone derived inhibitors of BCL6 THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-11-02 US disclosed
US-20210206756-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-07-08 US disclosed
US-20210163497-A1 BCL6 INHIBITORS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-06-03 US disclosed
US-20210163497-A1 BCL6 INHIBITORS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-06-03 US disclosed
EP-3774817-A1 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2021-02-17 EP disclosed
CN-112334475-A BCL6 inhibitor 癌症研究技术有限公司 2021-02-05 CN disclosed
EP-3630749-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 EP disclosed
WO-2019197842-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2019-10-17 WO disclosed
WO-2019197842-A1 BCL6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2019-10-17 WO disclosed
WO-2018215798-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210163497-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL3 MAPT 3855/4885F2RL3 1610/4885MEN1 708/4885
US-20230287003-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL3 MAPT 3855/4885F2RL3 1610/4885MEN1 708/4885
US-12486285-B2 BCL6 inhibitors BCL6, BCL6B, BCL3 MAPT 3855/4885F2RL3 1610/4885MEN1 708/4885
US-11161839-B2 2-quinolone derived inhibitors of BCL6 BCL6, BCL6B, BCL3 MAPT 4365/4885F2RL3 1522/4885MEN1 1152/4885
US-20260042776-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL9 MAPT 3429/4885F2RL3 2857/4885MEN1 2126/4885
US-20210206756-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 BCL6, BCL6B, BCL3 MAPT 4365/4885F2RL3 1522/4885MEN1 1152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.