Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | KDR | P35968 | 10/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.69 |
| ▸ | TNNI3K | Q59H18 | 10/20 | 0.69 |
| ▸ | BRAF | P15056 | 8/20 | 0.69 |
| ▸ | CDK8 | P49336 | 3/20 | 0.65 |
| ▸ | CDK7 | P50613 | 1/20 | 0.65 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568683 | 0.90 | MEN1 (0.74) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL6370472 | 0.86 | MAPT (0.72) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL5597699 | 0.85 | KMT2A (0.90) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL30101230 | 0.85 | KMT2A (0.90) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL30069239 | 0.84 | MAPT (1.00) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL17609423 | 0.84 | MAPT (1.00) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL4548162 | 0.83 | KMT2A (0.87) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL4548157 | 0.83 | MAPT (0.79) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL22092703 | 0.82 | MAPT (0.79) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL29494989 | 0.82 | MAPT (0.79) | KMT2AMEN1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | disclosed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |