Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28559569 | 0.87 | MAPK14 (0.57) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2084076 | 0.85 | MAPK14 (0.55) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2082582 | 0.84 | MAPK14 (0.76) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2079359 | 0.84 | MAP3K7 (0.63) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2082687 | 0.83 | MAP3K7 (0.64) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2083118 | 0.83 | MAPK14 (0.70) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2080978 | 0.83 | MAP3K7 (0.62) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2083711 | 0.83 | MAP3K7 (0.57) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2081550 | 0.83 | MAP3K7 (0.64) | MAP3K7MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2616940 | 0.83 | MAP3K7 (0.64) | MAP3K7MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | disclosed |