SCHEMBL20569749

SCHEMBL20569749

C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@H](C)C1(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 1.00
▸ ADRB3 P13945 1/20 1.00
▸ HTR1D P28221 1/20 1.00
▸ ADORA1 P30542 1/20 1.00
▸ OPRM1 P35372 1/20 1.00
▸ SLC6A3 Q01959 1/20 1.00
▸ TMEM97 Q5BJF2 1/20 1.00
▸ HRH3 Q9Y5N1 1/20 1.00
▸ NCOR2 Q9Y618 6/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29508721 1.00 BCL6 (1.00) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL23357584 0.95 BCL6 (0.91) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30745252 0.95 BCL6 (0.91) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30964545 0.95 BCL6 (0.90) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30964552 0.94 BCL6 (0.88) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30964547 0.94 BCL6 (0.88) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL20569891 0.92 BCL6 (0.86) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30745254 0.92 BCL6 (0.86) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30964527 0.92 BCL6 (0.85) BCL6ADRB3HTR1DADORA1OPRM1
SCHEMBL30964521 0.92 BCL6 (0.85) BCL6ADRB3HTR1DADORA1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12110286-B2 Benzimidazolone derived inhibitors of BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-10-08 — — US claimed
EP-3630291-B9 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 — — EP claimed
EP-3630291-B1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-01-10 — — EP claimed
EP-4061834-A1 CHEMICALLY INDUCIBLE POLYPEPTIDE POLYMERIZATION Dana-Farber Cancer Institute, Inc. (US) 2022-09-28 — — EP claimed
US-20220281931-A1 CHEMICALLY INDUCIBLE POLYPEPTIDE POLYMERIZATION DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-09-08 — — US claimed
WO-2021102283-A1 CHEMICALLY INDUCIBLE POLYPEPTIDE POLYMERIZATION DANA-FARBER CANCER INSTITUTE, INC. (US) 2021-05-27 — — WO claimed
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-05-20 — — US claimed
CN-111163839-A Benzimidazolone-derived BCL6 inhibitors 癌症研究科技有限公司 2020-05-15 — — CN claimed
US-20260130997-A1 METHODS AND COMPOSITIONS FOR ANTI-CD45 BASED NON-GENOTOXIC CONDITIONING BEAM THERAPEUTICS INC. (US) 2026-05-14 — — US disclosed
US-20260130907-A1 ALKYLAMINE-CONTAINING SMALL MOLECULE DEGRADERS OF BCL6 DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-05-14 — — US disclosed
EP-4729127-A2 BCL6 INHIBITORS Cancer Research Technology Limited (GB) 2026-04-22 — — EP disclosed
EP-4713005-A2 METHODS AND COMPOSITIONS FOR ANTI-CD45 BASED NON-GENOTOXIC CONDITIONING Beam Therapeutics Inc. (US) 2026-03-25 — — EP disclosed
US-20260042776-A1 BCL6 INHIBITORS CANCER RESEARCH TECH LTD (GB) 2026-02-12 — — US disclosed
US-12528826-B2 [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2026-01-20 — — US disclosed
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-05-20 — — US disclosed
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-05-20 — — US disclosed
WO-2021074620-A1 [1,4]OXAZEPINO[2,3-C]QUI NOLI NONE DERIVATIVES AS BLC6 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-04-22 — — WO disclosed
CN-111163839-A Benzimidazolone-derived BCL6 inhibitors 癌症研究科技有限公司 2020-05-15 — — CN disclosed
EP-3630291-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 — — EP disclosed
WO-2018215801-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12528826-B2 [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors BCL6, BCL6B, BCL3 BCL6 1/4885ADRB3 3587/4885HTR1D 1711/4885
US-20260130907-A1 ALKYLAMINE-CONTAINING SMALL MOLECULE DEGRADERS OF BCL6 BCL6, BCL6B, BCL9L BCL6 1/4885ADRB3 1818/4885HTR1D 2621/4885
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 BCL6, BCL6B, BCL3 BCL6 1/4885ADRB3 3749/4885HTR1D 2964/4885
US-20260130997-A1 METHODS AND COMPOSITIONS FOR ANTI-CD45 BASED NON-GENOTOXIC CONDITIONING BCR, CD2BP2, NSUN2 BCL6 674/4885ADRB3 3876/4885HTR1D 2254/4885
US-20260042776-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL9 BCL6 1/4885ADRB3 3596/4885HTR1D 514/4885
US-12110286-B2 Benzimidazolone derived inhibitors of BCL6 BCL6, BCL6B, BCL3 BCL6 1/4885ADRB3 3749/4885HTR1D 2964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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