Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Biotin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.87 |
| ▸ | MEN1 | O00255 | 1/20 | 0.87 |
| ▸ | ABL1 | P00519 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | PKM | P14618 | 1/20 | 0.87 |
| ▸ | IDE | P14735 | 1/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.87 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.87 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.87 |
| ▸ | HLCS | P50747 | 6/20 | 0.61 |
| ▸ | CA12 | O43570 | 6/20 | 0.53 |
| ▸ | CA1 | P00915 | 6/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | CA9 | Q16790 | 6/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biotin SCHEMBL453833 | 0.99 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL6865574 | 0.95 | TDP1 (0.87) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL15283293 | 0.95 | TDP1 (0.97) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL30842797 | 0.95 | TDP1 (0.97) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL7847236 | 0.95 | TDP1 (0.97) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL5960334 | 0.94 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL3425472 | 0.94 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL770770 | 0.94 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL739967 | 0.94 | TDP1 (0.85) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL20473405 | 0.94 | TDP1 (0.90) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021372-A1 | Compositions and methods for detection and isolation of phosphorylated molecules | Life Technologies Corporation (US) | 2011-01-27 | — | — | US | disclosed |
| US-7776533-B2 | Compositions and methods for detection and isolation of phosphorylated molecules | Life Technologies Corporation (US) | 2010-08-17 | — | — | US | disclosed |
| US-20100009381-A1 | Compositions and methods for detection and isolation of phosphorylated molecules | Life Technologies Corporation (US) | 2010-01-14 | — | — | US | disclosed |
| US-7445894-B2 | Compositions and methods for detection and isolation of phosphorylated molecules | MOLECULAR PROBES, INC. (US) | 2008-11-04 | — | — | US | disclosed |
| US-20080044804-A1 | COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES | INVITROGEN CORPORATION (US) | 2008-02-21 | — | — | US | disclosed |
| US-20070054304-A1 | COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES | INVITROGEN CORPORATION (US) | 2007-03-08 | — | — | US | disclosed |
| US-7102005-B2 | Compositions and methods for detection and isolation of phosphorylated molecules | MOLECULAR PROBES, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1546118-A2 | COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES | Molecular Probes Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005047901-A2 | COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION PHOSPHORYLATED MOLECULES | MOLECULAR PROBES, INC. (US) | 2005-05-26 | — | — | WO | disclosed |
| US-20050014197-A1 | Compositions and methods for detection and isolation of phosphorylated molecules | MOLECULAR PROBES, INC. | 2005-01-20 | — | — | US | disclosed |
| US-20040171034-A1 | Compositions and methods for detection and isolation of phosphorylated molecules | MOLECULAR PROBES, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2004042347-A2 | COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES | MOLECULAR PROBES, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
| US-20040038306-A1 | Compositions and methods for detection and isolation of phosphorylated molecules | MOLECULAR PROBES, INC. | 2004-02-26 | — | — | US | disclosed |
| US-6335176-B1 | REAGENT IS SUCCINIMIDYL MOIETY LINKED TO KINASE SUBSTRATE; CAN BE LINKED TO FREE PRIMARY OR SECONDARY AMINE IN COMPOUND TO BE PHOSPHORYLATED | PHARMACOPEIA, INC. | 2002-01-01 | — | — | US | disclosed |