Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | FAAH | O00519 | 2/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ADH1B | P00325 | 1/20 | 0.44 |
| ▸ | ADH1C | P00326 | 1/20 | 0.44 |
| ▸ | ADH1A | P07327 | 1/20 | 0.44 |
| ▸ | ADH4 | P08319 | 1/20 | 0.44 |
| ▸ | ADH7 | P40394 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28237378 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL9797186 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL27636267 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL9843844 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL10811082 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL7621332 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL28376186 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL1838179 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB | |
| SCHEMBL351275 | 1.00 | — | — | |
| SCHEMBL1834208 | 1.00 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563536-A | The active measurement of Lp-PLA2 | 旭化成制药株式会社 | 2019-04-02 | — | — | CN | disclosed |
| US-20180360859-A1 | Acyclic Nucleoside Phosphonate Diesters | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180360859-A1 | Acyclic Nucleoside Phosphonate Diesters | NTPCR, PNP, TYMP | TSHR 4302/4885FAAH 2559/4885TRPV1 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.