Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23523985 | 0.86 | CNR1 (0.38) | S1PR1CNR1CNR2NPC1RAB9A | |
| SCHEMBL30355403 | 0.86 | CNR1 (0.38) | S1PR1CNR1CNR2NPC1RAB9A | |
| SCHEMBL30355719 | 0.86 | S1PR1 (0.51) | S1PR1ACACBS1PR3ALOX5APMAOB | |
| SCHEMBL23523950 | 0.86 | S1PR1 (0.51) | S1PR1ACACBS1PR3ALOX5APMAOB | |
| SCHEMBL23524213 | 0.85 | PPARA (0.38) | S1PR1CNR1CNR2NPC1RAB9A | |
| SCHEMBL23523716 | 0.85 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30355571 | 0.85 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30355741 | 0.84 | MAPT (0.54) | S1PR1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23524290 | 0.84 | MAPT (0.54) | S1PR1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23524003 | 0.84 | S1PR1 (0.47) | S1PR1NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240317728-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | TREVENA, INC. | 2024-09-26 | — | — | US | disclosed |
| US-11912693-B2 | Compounds for modulating S1P1 activity and methods of using the same | TREVENA, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912693-B2 | Compounds for modulating S1P1 activity and methods of using the same | TREVENA, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912693-B2 | Compounds for modulating S1P1 activity and methods of using the same | TREVENA, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11884655-B2 | Compounds and methods of preparing compounds S1P1 modulators | TREVENA, INC. (US) | 2024-01-30 | — | — | US | disclosed |
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230114241-A1 | METHODS OF TREATING EPILEPSY USING THE SAME | TREVENA, INC. | 2023-04-13 | — | — | US | disclosed |
| EP-4061352-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | Trevena, Inc. (US) | 2022-09-28 | — | — | EP | disclosed |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2021-06-24 | — | — | US | disclosed |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2021101854-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | TREVENA, INC. (US) | 2021-05-27 | — | — | WO | disclosed |
| WO-2021101854-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | TREVENA, INC. (US) | 2021-05-27 | — | — | WO | disclosed |
| US-20210147402-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | TREVENA, INC. | 2021-05-20 | — | — | US | disclosed |
| US-20210147402-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | TREVENA, INC. | 2021-05-20 | — | — | US | disclosed |
| WO-2021046183-A1 | METHODS OF TREATING EPILEPSY USING THE SAME | TREVENA, INC. (US) | 2021-03-11 | — | — | WO | disclosed |
| EP-3638235-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | Trevena, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| CN-110831593-A | Compounds for modulating S1P1 activity and methods of use thereof | 特维娜有限公司 | 2020-02-21 | — | — | CN | disclosed |
| WO-2018231745-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. (US) | 2018-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240317728-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | S1PR1, S1PR2, S1PR5 | S1PR1 1/4885CNR1 29/4885CNR2 71/4885 |
| US-11884655-B2 | Compounds and methods of preparing compounds S1P1 modulators | S1PR1, S1PR2, S1PR5 | S1PR1 1/4885CNR1 29/4885CNR2 71/4885 |
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | S1PR1 1/4885CNR1 20/4885CNR2 38/4885 |
| US-20230114241-A1 | METHODS OF TREATING EPILEPSY USING THE SAME | S1PR1, S1PR2, S1PR3 | S1PR1 1/4885CNR1 10/4885CNR2 13/4885 |
| US-20210147402-A1 | COMPOUNDS AND METHODS OF PREPARING COMPOUNDS S1P1 MODULATORS | S1PR1, S1PR2, S1PR5 | S1PR1 1/4885CNR1 29/4885CNR2 71/4885 |
| US-11912693-B2 | Compounds for modulating S1P1 activity and methods of using the same | S1PR1, S1PR2, S1PR3 | S1PR1 1/4885CNR1 20/4885CNR2 38/4885 |
| US-20210188826-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | S1PR1 1/4885CNR1 20/4885CNR2 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.