Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.53 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257949 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2ALOX15PSMB5PSMB8MAPT | |
| SCHEMBL7949002 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2ALOX15MAPTTHRATHRB | |
| SCHEMBL17652414 | 0.81 | PSMB5 (0.46) | SMN1; SMN2PSMB5PSMB8MAPTTHRB | |
| SCHEMBL20587880 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2ALOX15PSMB5MAPTTHRA | |
| SCHEMBL7568303 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2ALOX15PSMB5PSMB8MAPT | |
| SCHEMBL7948483 | 0.80 | PSMB8 (0.56) | SMN1; SMN2ALOX15PSMB5PSMB8MAPT | |
| Hydrochloric Acid SCHEMBL10671160 | 0.79 | PSMB8 (0.55) | SMN1; SMN2ALOX15PSMB5PSMB8MAPT | |
| SCHEMBL20588781 | 0.78 | SMN1; SMN2 (0.73) | SMN1; SMN2ALOX15PSMB5MAPTTHRA | |
| SCHEMBL23360189 | 0.78 | MCL1 (0.51) | SMN1; SMN2PSMB5PSMB8MAPTMCL1 | |
| SCHEMBL1508206 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2ALOX15PSMB5MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200223837-A1 | BENZOFURAN AMIDES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2020-07-16 | — | — | US | disclosed |
| EP-3638664-A1 | BENZOFURAN AMIDES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY | European Molecular Biology Laboratory (DE) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018229193-A1 | BENZOFURAN AMIDES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2018-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200223837-A1 | BENZOFURAN AMIDES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY | SUCNR1, CBR1, CYP2A13 | SMN1; SMN2 1329/4885ALOX15 126/4885PSMB5 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.