Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824180 | 0.73 | MAPT (0.45) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL5010661 | 0.72 | GAA (0.41) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL1169394 | 0.70 | MAPT (0.52) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL12303975 | 0.70 | MAPT (0.51) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL10270125 | 0.70 | MAPT (0.51) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL824135 | 0.70 | MAPT (0.51) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL2061229 | 0.70 | MAPT (0.37) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL32678164 | 0.69 | MAPT (0.44) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL233475 | 0.69 | MAPT (0.51) | MAPTALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL13044811 | 0.68 | MAPT (0.47) | MAPTALDH1A1KMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148422-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-03 | — | — | US | disclosed |