Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24975198 | 0.91 | TP53 (0.56) | TP53THRBMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL10138104 | 0.87 | MAPK1 (0.57) | TP53MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL29598250 | 0.87 | MAPK1 (0.61) | TP53MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL2119508 | 0.84 | TP53 (0.53) | TP53THRBMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL31145166 | 0.83 | TDP1 (0.59) | TP53MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL2345470 | 0.83 | RXFP1 (0.55) | TP53THRBMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL18818444 | 0.83 | CA1 (0.59) | TP53MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL4469903 | 0.83 | TDP1 (0.59) | TP53MAPTSMN1; SMN2RXFP1KDM4E | |
| SCHEMBL4468880 | 0.81 | RXFP1 (0.66) | TP53THRBMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL2952102 | 0.81 | MAPT (0.51) | MAPTSMN1; SMN2RXFP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11142527-B2 | Dihydropyrimidine compounds and uses thereof in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| US-11142527-B2 | Dihydropyrimidine compounds and uses thereof in medicine | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| CN-109111451-B | Dihydropyrimidine compound and application thereof in medicine | 广东东阳光药业有限公司 | 2020-08-11 | — | — | CN | disclosed |
| US-20200115381-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED (CN) | 2020-04-16 | — | — | US | disclosed |
| US-20200115381-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED (CN) | 2020-04-16 | — | — | US | disclosed |
| WO-2019001396-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115381-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE | DPYD, SLC10A1, DHODH | TP53 134/4885THRB 3227/4885MAPT 24/4885 |
| US-11142527-B2 | Dihydropyrimidine compounds and uses thereof in medicine | DPYD, SLC10A1, DHODH | TP53 134/4885THRB 3227/4885MAPT 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.