Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29915315 | 0.83 | GRM5 (0.58) | GRM5CYP3A4 | |
| SCHEMBL6308517 | 0.80 | GRM5 (0.48) | GRM5TSHRPOLBALDH1A1HTT | |
| SCHEMBL29915494 | 0.79 | GRM5 (0.66) | GRM5CYP3A4 | |
| SCHEMBL13901291 | 0.78 | GRM5 (0.35) | GRM5LMNA | |
| SCHEMBL3126731 | 0.77 | GRM5 (0.45) | GRM5SMN1; SMN2 | |
| SCHEMBL20658743 | 0.77 | GRM5 (0.45) | GRM5SMN1; SMN2 | |
| SCHEMBL3126738 | 0.77 | GRM5 (0.45) | GRM5SMN1; SMN2 | |
| SCHEMBL3126917 | 0.77 | GRM5 (0.44) | GRM5ALDH1A1RECQLKDM4ELMNA | |
| SCHEMBL3126909 | 0.77 | GRM5 (0.44) | GRM5ALDH1A1RECQLKDM4ELMNA | |
| SCHEMBL22619524 | 0.75 | GRM5 (0.78) | GRM5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019002571-A1 | HETEROCYCLYLMETHYLIDENE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2019-01-03 | — | — | WO | disclosed |