Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17929361 | 0.94 | TOP2A (0.83) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7434524 | 0.89 | TOP2A (0.88) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2954779 | 0.88 | TOP2A (0.70) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL143232 | 0.88 | TOP2A (0.70) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL2964536 | 0.88 | TOP2A (0.70) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL206232 | 0.86 | TOP2A (0.56) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL28701666 | 0.85 | TOP2A (0.66) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL205455 | 0.85 | TOP2A (0.66) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17929350 | 0.84 | TOP2A (0.83) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7022264 | 0.84 | TOP2A (0.65) | TOP2AHSD17B10ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088760-B2 | Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090197863-A1 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197863-A1 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP11 | TOP2A 70/4885HSD17B10 1316/4885ALDH1A1 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.