Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 20/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | TDO2 | P48775 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554715 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL29618934 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL17742814 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL22693431 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL17747163 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL17747162 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL17747169 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL20620600 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL21034429 | 1.00 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 | |
| SCHEMBL22809002 | 0.91 | IDO1 (0.71) | IDO1CYP2C9CYP2C8CYP3A4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127233-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | BRISTOL MYERS SQUIBB CO (US) | 2022-04-28 | — | — | US | disclosed |
| US-11236048-B2 | Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200123109-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | BRISTOL-MYERS SQUIBB COMPANY | 2020-04-23 | — | — | US | disclosed |
| WO-2019006292-A1 | SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236048-B2 | Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation | QARS1, BCHE, NQO2 | IDO1 3315/4885CYP2C9 513/4885CYP2C8 69/4885 |
| US-20200123109-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | QARS1, BCHE, NQO2 | IDO1 3315/4885CYP2C9 513/4885CYP2C8 69/4885 |
| US-20220127233-A1 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION | QARS1, BCHE, NQO2 | IDO1 3315/4885CYP2C9 513/4885CYP2C8 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.