Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744058 | 0.84 | TP53 (0.35) | PAX8TP53ALDH1A1ATM | |
| SCHEMBL22200880 | 0.75 | KDM4E (0.39) | PAX8TP53JAK1ALDH1A1 | |
| SCHEMBL1272189 | 0.73 | TP53 (0.34) | PAX8TP53ALDH1A1ATM | |
| SCHEMBL22870065 | 0.73 | TP53 (0.34) | PAX8TP53JAK1ALDH1A1 | |
| SCHEMBL22870070 | 0.73 | TP53 (0.34) | PAX8TP53JAK1ALDH1A1 | |
| SCHEMBL24456475 | 0.72 | TP53 (0.43) | TP53ALDH1A1ATM | |
| SCHEMBL10289418 | 0.72 | TP53 (0.43) | TP53ALDH1A1ATM | |
| SCHEMBL15014638 | 0.72 | TP53 (0.43) | TP53ALDH1A1ATM | |
| SCHEMBL10728711 | 0.72 | — | — | |
| SCHEMBL17188547 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019006047-A1 | TDO2 AND IDO1 INHIBITORS | GENENTECH, INC. (US) | 2019-01-03 | — | — | WO | disclosed |